Regulation of neuron maturation

Across TCGA patient cohorts, RNA activity of the Regulation of neuron maturation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDLBP_S944, TNS2_S120, and TUBB6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuron maturation activity versus HDLBP_S944 in GBM (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HDLBP_S944 →	-0.786	-0.096	<.001	<.001	3	6
UCEC	TNS2_S120 →	+0.334	+0.045	.005	.002	3	5
LUAD	TUBB6 →	-0.210	-0.053	.007	.008	3	5
CCRCC	SLC9A3R2 →	+0.404	+0.083	.002	<.001	3	5
HNSC	TMSB10 →	-0.303	-0.079	.004	.002	3	5
BRCA	CACNA2D2 →	+0.705	+0.045	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014041 vs HDLBP_S944 — GBM

Explore this scatter interactively →