Regulation of neuron maturation

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of neuron maturation pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as COAD and HNSC, show the opposite pattern, with lower activity in tumor tissue.

COAD, HNSC, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	All	II,III,IV	−0.031	<.001	10	view →
HNSC	Male	IV	−0.075	<.001	8	view →
LUSC	Female	All	+0.073	<.001	5	view →
STAD	Female	All	−0.084	.008	4	view →
UCEC	All	II,III,IV	−0.054	.018	4	view →
BRCA	All	III,IV	−0.027	.015	4	view →
THCA	Male	II,III,IV	−0.044	.002	3	view →
READ	All	All	−0.063	.011	2	view →
PRAD	All	All	−0.035	<.001	2	view →
KICH	All	All	−0.033	.001	2	view →
THCA	Female	III,IV	+0.042	.003	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 10 lineages.

GO:0014041–COAD

Open the COAD breakdown →