Regulation of neuron maturation

Across TCGA cell cohorts, RNA activity of the Regulation of neuron maturation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC122, HSPA12A, and C10orf62, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC122 grouped by Regulation of neuron maturation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CCDC122 →	-1.088	-1.172	.003	.008	2	5
OVARY	HSPA12A →	-1.634	-1.148	.001	.002	3	4
LUNG_SCLC	C10orf62 →	-0.040	-1.309	.009	<.001	3	3
LIVER	ZNF423 →	-1.271	-1.366	.001	.007	3	3
URINARY_TRACT	DLC1 →	+2.430	+1.597	.007	<.001	3	3
URINARY_TRACT	ZBED2 →	-3.450	-1.854	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC122 by Regulation of neuron maturation activity — LIVER

Explore this box plot interactively →