Regulation of neuron maturation

Across TCGA cell cohorts, RNA activity of the Regulation of neuron maturation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K13, ADAMTS3, and PRDM5, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuron maturation activity versus MAP3K13 in BONE (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MAP3K13 →	+1.097	+0.612	<.001	<.001	3	14
URINARY_TRACT	ADAMTS3 →	-0.778	-0.418	.003	<.001	2	8
CNS	PRDM5 →	-0.800	-0.394	.002	.007	2	8
URINARY_TRACT	TANGO6 →	-1.025	-0.347	<.001	<.001	3	7
PANCREAS	KLHL42 →	-0.766	-0.225	.004	.003	3	6
BLOOD_Leukemia	CORO1C →	-0.956	-0.469	.002	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014041 vs MAP3K13 — BONE

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