Schwann cell differentiation

Across TCGA cell cohorts, RNA activity of the Schwann cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCD, SMKR1, and PPP4R1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Schwann cell differentiation activity versus PRKCD in BLOOD_Lymphoma (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRKCD →	+1.218	+0.283	<.001	.001	3	4
BLOOD_Lymphoma	SMKR1 →	-1.292	-0.182	<.001	.009	3	4
BREAST	PPP4R1 →	-1.195	-0.203	.003	.004	3	4
BREAST	SGMS1 →	-0.944	-0.259	<.001	<.001	3	4
SOFT_TISSUE	NOP9 →	-0.503	-0.269	.007	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	MVK →	+1.058	+0.263	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014037 vs PRKCD — BLOOD_Lymphoma

Explore this scatter interactively →