Neural crest cell fate commitment

Across TCGA patient cohorts, RNA activity of the Neural crest cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM32, SHC2, and RANBP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural crest cell fate commitment activity versus TRIM32 in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRIM32 →	+0.549	+0.915	.001	<.001	3	4
OV	SHC2 →	+1.228	+0.782	.001	.002	3	4
OV	RANBP2 →	+0.609	+0.717	.008	.001	3	4
LSCC	SFRP1 →	+1.075	+0.412	.001	.001	3	4
LSCC	WDR35 →	+0.592	+0.564	.002	.007	3	4
LSCC	MIR656 →	+0.581	+0.456	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014034 vs TRIM32 — BRCA

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