Neural crest cell fate commitment

Across TCGA cell cohorts, RNA activity of the Neural crest cell fate commitment pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R12A, AHCTF1, and CYP2W1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R12A grouped by Neural crest cell fate commitment-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PPP1R12A →	+0.386	+1.282	.007	<.001	3	4
SOFT_TISSUE	AHCTF1 →	-0.272	-1.339	.002	.005	3	4
SOFT_TISSUE	CYP2W1 →	-0.161	-1.183	.004	.007	3	4
STOMACH	STK40 →	+0.192	+0.331	<.001	.002	3	3
STOMACH	SMG6 →	-0.260	-0.388	<.001	.007	3	3
OESOPHAGUS	CYB561D2 →	-0.255	-1.319	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R12A by Neural crest cell fate commitment activity — CNS

Explore this box plot interactively →