Neural crest cell differentiation

Across TCGA patient cohorts, RNA activity of the Neural crest cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB3BP, MANEA-DT, and BLM, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural crest cell differentiation activity versus ITGB3BP in HNSC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ITGB3BP →	+0.527	+0.085	.006	.006	3	3
GBM	MANEA-DT →	+0.350	+0.503	.005	.001	3	3
OV	BLM →	+0.749	+0.201	.003	<.001	3	3
PDAC	LINC00638 →	+0.202	+0.092	.008	.007	3	3
COAD	OAS3 →	+0.950	+0.174	<.001	<.001	3	3
CCRCC	MIR924HG →	+0.258	+0.278	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014033 vs ITGB3BP — HNSC

Explore this scatter interactively →