Neural crest formation

Across TCGA patient cohorts, RNA activity of the Neural crest formation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA2, PARPBP, and SPDL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural crest formation activity versus CDCA2 in LUAD (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDCA2 →	+0.904	+0.210	.001	.002	3	6
BRCA	PARPBP →	+0.693	+0.217	<.001	<.001	3	6
BRCA	SPDL1 →	+0.644	+0.228	<.001	<.001	3	6
LSCC	CLSPN →	+0.704	+0.186	<.001	<.001	3	6
BRCA	SGO1 →	+0.740	+0.216	<.001	<.001	3	5
BRCA	NUF2 →	+1.163	+0.205	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014029 vs CDCA2 — LUAD

Explore this scatter interactively →