Neural crest formation

Across TCGA patient cohorts, RNA activity of the Neural crest formation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TCOF1_S233, TCOF1, and RFC1_S368, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural crest formation activity versus TCOF1_S233 in OV (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TCOF1_S233 →	+0.976	+0.348	<.001	<.001	3	7
OV	TCOF1 →	+0.432	+0.228	.001	.006	2	7
LSCC	RFC1_S368 →	+0.713	+0.216	<.001	<.001	3	5
BRCA	TOM1L2 →	-0.418	-0.211	<.001	<.001	2	6
LUAD	API5_S464 →	+0.804	+0.221	<.001	<.001	3	5
LUAD	NCL_S67 →	+0.993	+0.263	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014029 vs TCOF1_S233 — OV

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