Neural crest formation

Across TCGA cell cohorts, RNA activity of the Neural crest formation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCD6, KAT2B, and BRD9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural crest formation activity versus PDCD6 in PANCREAS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PDCD6 →	+0.947	+0.263	<.001	<.001	3	6
LUNG_SCLC	KAT2B →	-1.316	-0.164	.007	.008	3	5
OESOPHAGUS	BRD9 →	+0.881	+0.251	.005	.006	2	6
BLOOD_Leukemia	C5orf34 →	+0.995	+0.200	<.001	<.001	3	5
PANCREAS	NSUN2 →	+0.750	+0.261	<.001	<.001	3	5
OESOPHAGUS	GOLPH3 →	+0.840	+0.272	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014029 vs PDCD6 — PANCREAS

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