Negative regulation of gliogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of gliogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD8A, PLCL2, and GFI1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of gliogenesis activity versus CD8A in LUAD (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CD8A →	-0.707	-0.688	<.001	.001	3	4
COAD	PLCL2 →	-0.555	-0.624	.001	.001	3	4
LUAD	GFI1 →	-0.475	-0.721	.003	.003	3	4
COAD	RNF125 →	-0.671	-0.642	.008	.001	3	4
PDAC	CC2D2B →	-0.258	-0.625	.006	.009	3	4
LUAD	CSF2RB →	-0.518	-0.625	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014014 vs CD8A — LUAD

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