Negative regulation of gliogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of gliogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNNM4, OR2H1, and CRNN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNNM4 grouped by Negative regulation of gliogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CNNM4 →	-0.243	-1.298	.008	.004	3	8
SOFT_TISSUE	OR2H1 →	-0.285	-1.390	.005	.001	3	7
BREAST	CRNN →	-0.226	-0.797	.001	<.001	3	7
BLOOD_Myeloma	DLX2 →	-0.459	-2.025	.001	<.001	3	6
CNS	CFB →	-0.264	-1.730	.002	<.001	3	6
SKIN	TP53 →	-0.973	-1.526	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNNM4 by Negative regulation of gliogenesis activity — LIVER

Explore this box plot interactively →