Negative regulation of gliogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of gliogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FUT1, BICDL2, and CDC42BPG, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FUT1 grouped by Negative regulation of gliogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FUT1 →	+2.327	+1.346	<.001	<.001	3	7
BREAST	BICDL2 →	+1.878	+0.741	.002	.005	3	7
LUNG_SCLC	CDC42BPG →	+2.362	+0.959	.001	.006	3	6
BONE	ARHGEF16 →	+2.430	+1.464	.002	<.001	3	6
LUNG_SCLC	BSPRY →	+3.025	+1.241	<.001	<.001	3	5
LUNG_SCLC	GADD45G →	+3.418	+0.999	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FUT1 by Negative regulation of gliogenesis activity — LUNG_SCLC

Explore this box plot interactively →