Negative regulation of gliogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of gliogenesis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTMS, MKS1, and IDH2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of gliogenesis activity versus PTMS in URINARY_TRACT (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PTMS →	-2.527	-0.428	.008	.003	3	5
LARGE_INTESTINE	MKS1 →	-0.568	-0.309	.001	.004	3	4
BLOOD_Myeloma	IDH2 →	+5.662	+1.971	<.001	<.001	3	4
BONE	AIG1 →	+3.088	+1.213	.002	.009	3	4
BONE	POU6F1 →	-1.304	-0.948	.003	.005	3	4
BLOOD_Myeloma	TMEM237 →	-0.998	-1.553	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014014 vs PTMS — URINARY_TRACT

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