Regulation of gliogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of gliogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPING1, C1QA, and C1QC, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gliogenesis activity versus SERPING1 in BRCA (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPING1 →	+0.631	+0.042	<.001	<.001	3	9
CCRCC	C1QA →	+0.680	+0.049	<.001	<.001	3	8
GBM	C1QC →	+0.577	+0.046	.001	<.001	3	8
CCRCC	C1R →	+0.638	+0.053	<.001	<.001	3	8
CCRCC	C1S →	+0.569	+0.058	<.001	<.001	3	8
OV	C4BPA →	+0.470	+0.029	.006	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014013 vs SERPING1 — BRCA

Explore this scatter interactively →