Regulation of gliogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of gliogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFIP11, CCDC12, and SDC3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TFIP11 grouped by Regulation of gliogenesis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TFIP11 →	-0.666	-0.257	.009	.006	3	3
BLOOD_Lymphoma	CCDC12 →	-1.396	-0.313	.005	.001	3	3
BLOOD_Lymphoma	SDC3 →	-0.676	-0.382	.001	.004	3	3
UPPER_AERODIGESTIVE_TRACT	ZMYM2 →	+1.256	+0.217	<.001	<.001	3	3
CNS	ENO1 →	-0.787	-0.887	<.001	.004	3	3
CNS	PLOD1 →	-1.214	-0.757	.009	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TFIP11 by Regulation of gliogenesis activity — BLOOD_Lymphoma

Explore this box plot interactively →