Peripheral nervous system axon regeneration

Across TCGA patient cohorts, RNA activity of the Peripheral nervous system axon regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FILIP1L, VCL, and DPYSL3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peripheral nervous system axon regeneration activity versus FILIP1L in CCRCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FILIP1L →	+0.719	+0.172	<.001	<.001	3	9
COAD	VCL →	+0.437	+0.064	.001	.007	3	8
COAD	DPYSL3 →	+0.621	+0.062	<.001	<.001	3	8
LSCC	MAP1B →	+0.774	+0.081	<.001	.002	3	8
HNSC	PDLIM3 →	+0.844	+0.069	<.001	<.001	3	8
HNSC	SYNPO2 →	+0.743	+0.078	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014012 vs FILIP1L — CCRCC

Explore this scatter interactively →