Peripheral nervous system axon regeneration

Across TCGA cell cohorts, RNA activity of the Peripheral nervous system axon regeneration pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFK, ATP6V1B1, and WDR31, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RFK grouped by Peripheral nervous system axon regeneration-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RFK →	-0.436	-0.842	.008	.006	3	4
LUNG_NSCLC_LUAD	ATP6V1B1 →	+1.161	+0.939	.001	<.001	3	4
LIVER	WDR31 →	+0.835	+1.394	<.001	<.001	3	4
BLOOD_Lymphoma	TNFRSF11A →	+1.870	+1.397	.001	.004	3	4
BONE	PANO1 →	+0.478	+1.195	.008	.004	3	4
BLOOD_Leukemia	GPS2 →	-0.782	-1.045	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RFK by Peripheral nervous system axon regeneration activity — LARGE_INTESTINE

Explore this box plot interactively →