Glial cell proliferation

Across TCGA cell cohorts, RNA activity of the Glial cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RB1, TP53, and NFIA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RB1 grouped by Glial cell proliferation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RB1 →	-0.319	-1.180	.001	.005	3	6
SKIN	TP53 →	-0.755	-1.137	.001	<.001	3	6
STOMACH	NFIA →	-0.262	-1.275	<.001	<.001	3	6
BONE	PRDM1 →	-0.373	-1.706	<.001	<.001	3	6
LUNG_NSCLC_LUSC	PPFIBP1 →	-0.327	-1.196	.003	.009	2	7
CNS	FGF18 →	-0.218	-1.044	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RB1 by Glial cell proliferation activity — OVARY

Explore this box plot interactively →