Microglia differentiation

Across TCGA patient cohorts, RNA activity of the Microglia differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNX9, SSC5D, and ACTR2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microglia differentiation activity versus SNX9 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNX9 →	+0.421	+0.075	<.001	<.001	3	9
BRCA	SSC5D →	+0.656	+0.036	.001	.007	3	9
BRCA	ACTR2 →	+0.268	+0.058	<.001	<.001	3	9
BRCA	BYSL →	-0.275	-0.036	.001	.002	3	9
OV	C1QA →	+0.849	+0.065	<.001	.001	3	9
OV	C1QC →	+0.924	+0.089	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014004 vs SNX9 — OV

Explore this scatter interactively →