Microglia differentiation

Across TCGA patient cohorts, RNA activity of the Microglia differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC30A1, FAM20A, and LRRC25, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microglia differentiation activity versus SLC30A1 in UCEC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC30A1 →	-0.555	-0.616	.006	.001	3	4
BRCA	FAM20A →	+0.703	+0.292	<.001	.001	3	4
BRCA	LRRC25 →	+0.519	+0.255	<.001	<.001	3	4
BRCA	LINC01943 →	+0.745	+0.312	<.001	.005	2	5
BRCA	LCP2 →	+0.603	+0.275	<.001	<.001	3	4
BRCA	FCGR2B →	+0.704	+0.356	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014004 vs SLC30A1 — UCEC

Explore this scatter interactively →