Microglia differentiation

Across TCGA cell cohorts, RNA activity of the Microglia differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DERA, QKI, and HID1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microglia differentiation activity versus DERA in CNS (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DERA →	-1.169	-0.337	.001	.007	3	3
BREAST	QKI →	+1.835	+1.753	.009	<.001	3	3
BREAST	HID1 →	-4.558	-1.480	.003	.001	3	3
BREAST	MCRIP2 →	-1.379	-1.584	<.001	<.001	3	3
LUNG_SCLC	BTN3A2 →	+2.192	+1.309	.006	.002	3	3
LUNG_NSCLC_LUAD	PPARGC1A →	-1.739	-0.886	.009	.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014004 vs DERA — CNS

Explore this scatter interactively →