Microglia differentiation

Across TCGA cell cohorts, RNA activity of the Microglia differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APP, NR3C1, and RARS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microglia differentiation activity versus APP in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	APP →	+1.271	+0.880	<.001	<.001	3	9
CNS	NR3C1 →	-0.941	-0.217	.002	.003	3	5
CNS	RARS1 →	-0.494	-0.167	.001	.002	3	4
CNS	COPS3 →	-0.578	-0.232	.001	<.001	3	4
CNS	COPG2 →	-0.566	-0.165	.002	.002	3	4
CNS	PSMB4 →	-0.490	-0.177	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014004 vs APP — LUNG_NSCLC_LUAD

Explore this scatter interactively →