Oligodendrocyte development

Across TCGA cell cohorts, RNA activity of the Oligodendrocyte development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTP1, THUMPD2, and VWF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligodendrocyte development activity versus GSTP1 in BLOOD_Lymphoma (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GSTP1 →	+2.594	+0.709	.003	.002	2	5
BREAST	THUMPD2 →	-0.563	-0.925	.004	.002	3	4
LIVER	VWF →	+0.221	+2.244	.003	<.001	3	3
STOMACH	ZNF205 →	-0.545	-0.222	.004	.002	3	3
LIVER	DDX56 →	-0.684	-1.510	.001	.006	3	3
LIVER	TMEM134 →	+1.679	+2.011	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014003 vs GSTP1 — BLOOD_Lymphoma

Explore this scatter interactively →