Response to auditory stimulus

Across TCGA cell cohorts, RNA activity of the Response to auditory stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KATNAL2, TOB2, and UBQLN2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KATNAL2 grouped by Response to auditory stimulus-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KATNAL2 →	+1.739	+1.229	<.001	.001	3	3
LUNG_NSCLC_LUAD	TOB2 →	+0.488	+0.911	.006	<.001	3	3
SOFT_TISSUE	UBQLN2 →	-0.561	-0.822	.006	.009	3	3
SOFT_TISSUE	TFDP1 →	-0.739	-1.250	.001	.001	3	3
LARGE_INTESTINE	ITPKA →	-1.116	-0.784	.007	.003	3	3
URINARY_TRACT	INAFM1 →	-1.356	-1.699	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KATNAL2 by Response to auditory stimulus activity — OVARY

Explore this box plot interactively →