Response to auditory stimulus

Across TCGA cell cohorts, RNA activity of the Response to auditory stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PACRGL, FZD6, and PDIA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to auditory stimulus activity versus PACRGL in LUNG_SCLC (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PACRGL →	-1.043	-0.909	.001	.009	3	4
BLOOD_Leukemia	FZD6 →	-1.929	-0.648	.003	.006	3	3
BLOOD_Leukemia	PDIA4 →	+0.995	+0.509	.006	.004	3	2
LARGE_INTESTINE	UST →	-2.130	-0.793	<.001	.001	3	2
LUNG_SCLC	WDR55 →	+0.784	+1.157	.001	.001	3	2
LUNG_SCLC	KRBOX4 →	-0.766	-1.042	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010996 vs PACRGL — LUNG_SCLC

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