Free ubiquitin chain polymerization

Across TCGA patient cohorts, RNA activity of the Free ubiquitin chain polymerization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HS2ST1, ACBD3, and SS18L2P1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Free ubiquitin chain polymerization activity versus HS2ST1 in COAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HS2ST1 →	-0.420	-0.654	.001	.005	3	3
BRCA	ACBD3 →	-0.582	-0.446	.001	.001	3	3
BRCA	SS18L2P1 →	+0.305	+0.333	.006	.004	3	3
UCEC	METTL4 →	+0.390	+0.518	<.001	<.001	3	3
UCEC	UBE2S →	+0.829	+0.561	<.001	.007	3	3
UCEC	NCAPG →	+0.795	+0.624	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010994 vs HS2ST1 — COAD

Explore this scatter interactively →