Ubiquitin recycling

Across TCGA patient cohorts, RNA activity of the Ubiquitin recycling pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR4257, RN7SL378P, and BMPR2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin recycling activity versus MIR4257 in HNSC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR4257 →	-1.179	-0.117	<.001	.004	3	3
HNSC	RN7SL378P →	-0.691	-0.129	<.001	.003	3	3
LUAD	BMPR2 →	-0.229	-0.263	.003	.006	3	2
HNSC	TNNT3 →	-1.558	-0.125	.006	.001	2	3
CCRCC	DUSP6 →	-0.534	-0.416	.009	.009	3	2
CCRCC	VEGFC →	-0.681	-0.563	.003	.004	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010992 vs MIR4257 — HNSC

Explore this scatter interactively →