Regulation of low-density lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Regulation of low-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL2A, PRMT3, and SLC25A39, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of low-density lipoprotein particle clearance activity versus METTL2A in URINARY_TRACT (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	METTL2A →	-0.553	-0.240	.008	.001	3	6
PANCREAS	PRMT3 →	-1.194	-0.227	.001	.001	3	6
STOMACH	SLC25A39 →	-0.778	-0.236	<.001	<.001	3	5
SOFT_TISSUE	CEP76 →	-0.446	-0.117	.005	.005	3	5
PANCREAS	MRPL30 →	-0.613	-0.219	.007	.006	3	5
LARGE_INTESTINE	RPL3 →	-0.762	-0.195	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010988 vs METTL2A — URINARY_TRACT

Explore this scatter interactively →