Positive regulation of lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Positive regulation of lipoprotein particle clearance pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYH11_S1347, MYH11_S1354, and LAMB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipoprotein particle clearance activity versus MYH11_S1347 in HNSC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MYH11_S1347 →	-0.635	-0.073	<.001	<.001	3	5
HNSC	MYH11_S1354 →	-0.635	-0.073	<.001	<.001	3	5
HNSC	LAMB2 →	-0.530	-0.057	<.001	<.001	3	5
LSCC	TMPO_S378 →	-0.613	-0.060	.004	<.001	3	4
CCRCC	CHAMP1_S108 →	-0.249	-0.058	.002	.002	3	4
OV	SRF →	-0.835	-0.057	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010986 vs MYH11_S1347 — HNSC

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