Regulation of lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Regulation of lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the SARC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYROBP, TREM2, and SPI1, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipoprotein particle clearance activity versus TYROBP in SARC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	TYROBP →	+1.763	+0.076	<.001	<.001	3	29
THYM	TREM2 →	+1.846	+0.048	<.001	<.001	3	29
SARC	SPI1 →	+1.509	+0.074	<.001	<.001	3	28
CHOL	APOC1 →	+2.255	+0.084	.002	.002	3	27
SARC	TNFAIP8L2 →	+1.447	+0.071	<.001	<.001	3	27
SARC	CD14 →	+1.788	+0.069	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010984 vs TYROBP — SARC

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