Regulation of lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Regulation of lipoprotein particle clearance pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LGALS9, SAMD9, and SH3BGRL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipoprotein particle clearance activity versus LGALS9 in CCRCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LGALS9 →	+0.382	+0.032	.004	.007	3	5
OV	SAMD9 →	+0.559	+0.050	<.001	<.001	3	4
LSCC	SH3BGRL3 →	+0.203	+0.046	<.001	.002	3	4
LSCC	BCL3 →	+0.216	+0.047	.001	.002	3	4
LSCC	HMGCS1_S4 →	+0.573	+0.050	.003	.001	3	4
LSCC	ORC6_T195 →	-0.960	-0.088	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010984 vs LGALS9 — CCRCC

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