Regulation of lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Regulation of lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JOSD2, CENATAC, and VPS26B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JOSD2 grouped by Regulation of lipoprotein particle clearance-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	JOSD2 →	+1.242	+0.278	.003	.007	2	5
LIVER	CENATAC →	+1.253	+1.675	.009	.007	3	4
BREAST	VPS26B →	+0.763	+0.294	<.001	<.001	3	3
BREAST	TYSND1 →	+0.632	+0.222	.001	.003	2	4
BREAST	TIGD6 →	+0.615	+0.312	.003	.002	3	3
BREAST	PIDD1 →	+0.822	+0.253	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JOSD2 by Regulation of lipoprotein particle clearance activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →