Regulation of lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Regulation of lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL3, CRLF3, and KIAA0753, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipoprotein particle clearance activity versus RPL3 in STOMACH (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RPL3 →	-1.184	-0.284	.004	.003	3	5
URINARY_TRACT	CRLF3 →	-0.964	-0.399	.001	<.001	3	5
URINARY_TRACT	KIAA0753 →	-0.702	-0.384	.002	.001	3	5
BREAST	RPS2 →	-0.592	-0.158	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	RNF8 →	-0.515	-0.208	.001	.005	3	5
PANCREAS	MR1 →	+1.604	+0.255	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010984 vs RPL3 — STOMACH

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