Positive regulation of high-density lipoprotein particle clearance

Across TCGA cell cohorts, RNA activity of the Positive regulation of high-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL3, HNRNPF, and B4GALT4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL3 grouped by Positive regulation of high-density lipoprotein particle clearance-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RPL3 →	-1.033	-1.505	.005	.004	3	6
UPPER_AERODIGESTIVE_TRACT	HNRNPF →	-0.865	-1.432	.005	.001	3	4
UPPER_AERODIGESTIVE_TRACT	B4GALT4 →	+1.173	+1.812	.002	.001	3	4
LUNG_NSCLC_LUSC	CPEB4 →	+1.304	+1.299	.002	<.001	3	4
LARGE_INTESTINE	RPL41 →	-0.926	-1.828	.002	<.001	3	4
LUNG_SCLC	HNRNPA1 →	-0.581	-1.496	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL3 by Positive regulation of high-density lipoprotein particle clearance activity — LARGE_INTESTINE

Explore this box plot interactively →