Positive regulation of neuron projection development

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuron projection development pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF621, LMTK2, and MORN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF621 grouped by Positive regulation of neuron projection development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF621 →	+0.220	+0.185	.006	.002	3	4
LUNG_SCLC	LMTK2 →	-0.297	-0.203	.004	<.001	3	4
CNS	MORN4 →	+0.270	+0.315	.006	.001	3	3
CNS	OR2L5 →	+0.163	+0.292	.007	<.001	3	3
OVARY	FANCF →	+0.122	+0.194	<.001	.001	3	3
OVARY	RAB21 →	-0.283	-0.219	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF621 by Positive regulation of neuron projection development activity — LUNG_SCLC

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