Positive regulation of neuron projection development

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of neuron projection development pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 157 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Positive regulation of neuron projection development pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and UCS, show the opposite pattern, with higher activity associated with better survival.

LIHC, UVM, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.662	0.832	<.001	88	view →
UVM	DFS	Tertile	III,IV	0.230	0.791	.005	63	view →
UCEC	OS	Quartile	All	0.893	0.954	.008	60	view →
KICH	OS	Median	III,IV	0.178	0.847	<.001	60	view →
LGG	DFS	Median	All	0.627	0.796	<.001	49	view →
SCLC	OS	Quartile	II,III,IV	0.702	0.203	.001	31	view →
UCS	DFS	Tertile	III,IV	0.421	0.103	.015	30	view →
HNSC	DFS	Median	III,IV	0.664	0.515	.003	30	view →
OV	OS	Quartile	III,IV	0.762	0.875	.007	26	view →
DLBC	DFS	Median	III,IV	1.000	0.457	.003	17	view →
PAAD	DFS	Tertile	II,III,IV	0.631	0.354	.040	8	view →
PCPG	DFS	Tertile	All	1.000	0.706	.012	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0010976–LIHC (OS)

Open the LIHC breakdown →