Positive regulation of neuron projection development

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuron projection development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K5, CD44, and PDLIM7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuron projection development activity versus MAP4K5 in OVARY (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MAP4K5 →	+1.433	+0.244	<.001	<.001	3	6
LIVER	CD44 →	+6.624	+0.280	<.001	.002	3	6
BONE	PDLIM7 →	+2.427	+0.335	<.001	<.001	3	6
OVARY	SERINC1 →	+0.618	+0.182	.001	<.001	3	5
LIVER	AHNAK →	+2.219	+0.266	.005	.005	2	6
OVARY	TWSG1 →	+1.021	+0.126	.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010976 vs MAP4K5 — OVARY

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