Transport along microtubule

Across TCGA patient cohorts, RNA activity of the Transport along microtubule pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRPA1, BBC3, and TYRP1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transport along microtubule activity versus TRPA1 in COAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRPA1 →	+1.593	+1.365	<.001	.003	3	1
COAD	BBC3 →	-0.516	-1.300	.003	.001	3	1
COAD	TYRP1 →	+0.940	+1.206	<.001	.006	3	1
COAD	TMEM97 →	+0.768	+1.335	.001	.003	3	1
COAD	TFEB →	-0.503	-1.278	.005	<.001	3	1
COAD	REG1A →	+4.845	+1.303	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010970 vs TRPA1 — COAD

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