Regulation of microtubule nucleation

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule nucleation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MACROH2A1, CRACR2A, and MEN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MACROH2A1 grouped by Regulation of microtubule nucleation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MACROH2A1 →	-0.898	-0.556	.005	<.001	3	4
LUNG_NSCLC_LUSC	CRACR2A →	+2.728	+0.296	<.001	.003	3	3
LUNG_NSCLC_LUSC	MEN1 →	-0.513	-0.290	.001	.003	2	4
OVARY	SNAP47 →	-0.605	-0.250	<.001	.009	2	4
KIDNEY	RDM1 →	-1.414	-0.265	<.001	.007	3	3
BLOOD_Leukemia	SIRT6 →	+0.649	+0.244	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MACROH2A1 by Regulation of microtubule nucleation activity — BLOOD_Myeloma

Explore this box plot interactively →