Regulation of microtubule nucleation

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule nucleation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAUS5, CLSPN, and ASPM, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule nucleation activity versus HAUS5 in BONE (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HAUS5 →	+1.437	+0.154	<.001	<.001	3	18
SKIN	CLSPN →	+1.626	+0.104	<.001	<.001	3	17
BLOOD_Lymphoma	ASPM →	+1.296	+0.108	<.001	<.001	3	17
SOFT_TISSUE	BUB1B →	+1.359	+0.097	<.001	<.001	3	17
PANCREAS	SPC24 →	+1.466	+0.100	<.001	<.001	3	16
PANCREAS	KIF18B →	+1.677	+0.097	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010968 vs HAUS5 — BONE

Explore this scatter interactively →