Regulation of microtubule nucleation

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule nucleation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NMT2, FAM3A, and ASXL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule nucleation activity versus NMT2 in LIVER (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NMT2 →	+1.941	+0.391	.001	.008	3	4
LIVER	FAM3A →	+1.261	+0.447	.001	<.001	3	4
LUNG_NSCLC_LUAD	ASXL1 →	+0.750	+0.321	<.001	.003	3	4
BLOOD_Lymphoma	DENND1B →	-1.211	-0.289	.001	.001	3	4
BLOOD_Leukemia	TFR2 →	-2.559	-0.290	<.001	.005	3	3
LARGE_INTESTINE	IPP →	-0.503	-0.252	.002	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010968 vs NMT2 — LIVER

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