Regulation of phosphate transport

Across TCGA cell cohorts, RNA activity of the Regulation of phosphate transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LTBP1, YDJC, and ELMOD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LTBP1 grouped by Regulation of phosphate transport-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LTBP1 →	-1.702	-1.367	.003	<.001	3	4
CNS	YDJC →	+0.864	+0.902	.002	.003	3	3
CNS	ELMOD2 →	-0.369	-1.108	.008	.001	3	3
BREAST	FGFBP1 →	+2.258	+0.958	.004	<.001	3	3
STOMACH	PAIP2B →	+1.420	+1.542	.002	.001	3	3
BONE	GTF3C2 →	+0.582	+1.656	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LTBP1 by Regulation of phosphate transport activity — PANCREAS

Explore this box plot interactively →