Magnesium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Magnesium ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TBC1D2B, WIPF1, and CAMSAP3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Magnesium ion homeostasis activity versus TBC1D2B in BRCA (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TBC1D2B →	-0.305	-0.059	<.001	<.001	3	8
BRCA	WIPF1 →	-0.437	-0.047	<.001	<.001	3	7
GBM	CAMSAP3 →	+0.630	+0.107	<.001	<.001	3	7
HNSC	GFPT2 →	-0.540	-0.074	.001	<.001	3	7
LUAD	ANK3 →	+0.365	+0.066	.004	.002	3	7
BRCA	NECAP2 →	-0.268	-0.047	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010960 vs TBC1D2B — BRCA

Explore this scatter interactively →