Magnesium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Magnesium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK3, FCGR2B, and LOXL2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Magnesium ion homeostasis activity versus ANK3 in GBM (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANK3 →	+1.435	+0.683	<.001	<.001	3	10
GBM	FCGR2B →	-1.017	-0.472	<.001	.001	3	8
PDAC	LOXL2 →	-1.102	-0.411	<.001	<.001	3	7
LUAD	SERPINE1 →	-0.944	-0.351	<.001	.005	3	6
LUAD	ARL4AP1 →	+0.638	+0.342	<.001	<.001	3	6
GBM	IL2RA →	-1.066	-0.357	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010960 vs ANK3 — GBM

Explore this scatter interactively →