Magnesium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Magnesium ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANK3_S1459, ANK3, and ANK3_S959, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Magnesium ion homeostasis activity versus ANK3_S1459 in CCRCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ANK3_S1459 →	+1.239	+0.683	<.001	<.001	3	9
CCRCC	ANK3 →	+0.673	+0.658	<.001	<.001	3	8
BRCA	ANK3_S959 →	+1.341	+0.667	<.001	.001	2	8
CCRCC	ANK3_S4229 →	+0.870	+0.764	<.001	<.001	3	6
PDAC	CAMSAP3_S334 →	+0.582	+0.309	<.001	<.001	3	5
LUAD	DDAH1 →	+0.655	+0.526	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010960 vs ANK3_S1459 — CCRCC

Explore this scatter interactively →