Magnesium ion homeostasis

Across TCGA cell cohorts, RNA activity of the Magnesium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMC6, KIAA1522, and SEPTIN10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Magnesium ion homeostasis activity versus TMC6 in LUNG_NSCLC_LUAD (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TMC6 →	+2.091	+0.407	.003	.003	3	3
LUNG_NSCLC_LUAD	KIAA1522 →	+0.876	+0.423	<.001	<.001	3	3
LUNG_NSCLC_LUAD	SEPTIN10 →	-0.987	-0.415	.003	<.001	3	3
LUNG_NSCLC_LUSC	SYNE1 →	-2.333	-0.664	.002	<.001	3	3
LARGE_INTESTINE	ITGB1 →	-0.886	-0.360	.004	.001	3	3
LARGE_INTESTINE	NMT2 →	-0.913	-0.286	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010960 vs TMC6 — LUNG_NSCLC_LUAD

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