Cellular component assembly involved in morphogenesis

Across TCGA cell cohorts, RNA activity of the Cellular component assembly involved in morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHCHD2, LYRM9, and RGS11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHCHD2 grouped by Cellular component assembly involved in morphogenesis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CHCHD2 →	+0.842	+2.009	.001	<.001	3	4
OVARY	LYRM9 →	-1.426	-1.171	<.001	<.001	3	4
OVARY	RGS11 →	-0.872	-0.863	.006	.005	3	4
LUNG_NSCLC_LUAD	EIF3B →	+0.657	+0.367	.001	.008	3	4
BLOOD_Leukemia	CHAC2 →	+0.854	+0.959	.009	.002	3	4
BLOOD_Leukemia	ABCE1 →	+0.553	+0.650	.004	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHCHD2 by Cellular component assembly involved in morphogenesis activity — BLOOD_Lymphoma

Explore this box plot interactively →