Regulation of phosphatase activity

Across TCGA patient cohorts, RNA activity of the Regulation of phosphatase activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1, TBC1D2B, and YME1L1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phosphatase activity activity versus TLN1 in BRCA (Pearson r = -0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TLN1 →	+0.313	+0.039	<.001	<.001	3	9
GBM	TBC1D2B →	+0.309	+0.053	<.001	<.001	3	9
BRCA	YME1L1 →	-0.378	-0.036	<.001	<.001	3	9
LSCC	AP2A1 →	+0.197	+0.058	<.001	<.001	3	9
GBM	RIN3 →	+0.326	+0.044	<.001	<.001	3	8
CCRCC	THBS2 →	+1.521	+0.037	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010921 vs TLN1 — BRCA

Explore this scatter interactively →